Epion

Average: 5 (1 vote)

•    Sedative, anti-anxiety and antidepressant
•    Improve sleep disorders based on nervous disorders
•    Spasmolytic & muscle relaxing

Producing country: 
Iran
Pharmaceutical form: 
Entric Coated Tablet
Indications: 
Sedative, anti-anxiety and antidepressant
Improve sleep disorders based on nervous disorders
Spasmolytic & muscle relaxing
Administration and Dosage: 

Children between 6-12 years old: take 1-3 tablets a day after consulting a physician.
Adults: 1-2 tablets three times a day (maximum dose is up to 5 tablets a day).
In case of insomnia, 1-2 tablets should be taken with liquids one to two hours before sleep.
Do not break the tablet in half.
This drug can be used at any time.
 

Technical Specifications: 

This product is made from high quality local and imported herbs organically planted and ‎harvested. It has been formulated by ‎Iran Darouk Pharmaceuticals.‎
 

Expiry date: 
2 Years
Drug interactions: 

Concurrent use of this medicine with benzodiazepines and barbiturates increases the sedative effects.
Should not be used concurrently with anticoagulants such as heparin and warfarin.
Concurrent use of this medicine with digoxin is not recommended.
Concurrent use of this medicine with immunosuppressive drugs (cyclosporine, tacrolimus, and sirolimus), protease inhibitors or non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are used to treat HIV, and cytostatic drugs except monoclonal antibodies, is not recommended.
It is not recommended to use this medicine concurrently with alcohol.
Concurrent use of this medicine with drugs metabolized by cytochrome P450 may decrease the concentration of medicine such as oral contraceptives, cyclosporine, anticonvulsants, and carbamazepine.
Concurrent use of Epion with serotonergic drugs (nefazodone, paroxetine) and SSRIs may increase such adverse effects as nausea, vomiting and agitation.
The use of this medicine with theophylline, verapamil, simvastatin, and midazolam, can decrease their pharmacological effects.
Consult a physician if this drug is used simultaneously with drugs with the same mechanism of action (MAO inhibitors).‎
 

Physical characteristics: 
Pack of 10 tablets × 3 blisters in a cardboard box; patient information leaflet inside.
Storage: 

Store in a dry place, keep away from direct sunlight and below 25 °C.
Keep out of sight and reach of children.

‎Disposal 
Do not put into sewer lines. Dispose in the everyday rubbish bin.‎

Contraindications and precautions: 

When NOT to take it 
•    Should not be used in children under 6 years old.
•    Individuals with photosensitivity should avoid using this drug. If used, they should avoid exposure to UV radiation.
•    When working with heavy machinery: there is a chance of drowsiness for individuals that take this drug for the first time.

Side effects 
•    This drug has no mentionable adverse effects. Although, there are a few reports of gastrointestinal problems, allergic reactions, and sedation at the beginning of treatment.
 

Use during pregnancy and lactation: 

Should NOT be used during pregnancy and breast-feeding.
 

Product ID: 
6829545776852426
Mechanism of Action: 
Clinical trials show that Valeriana officinalis has sedative effects, which are mostly related to its volatile oils. Biochemical studies show that Valerenic Acid inhibits Gamma-Aminobutyric Acid (GABA) catabolism in the synaptic connections in the central nervous system. This leads to high concentrations of GABA in the brain tissue which causes sedative effects. Hypericum perforatum L and Passiflora incarnata L with a similar mechanism of action of valerian, as well as by inhibiting the activity of Monoamine Oxidase (MAO) enzyme and increasing the exchange neurotransmitters such as serotonin, norepinephrine and dopamine in the central nervous system, lead to sustainable sedative effects.  
Active Ingredients and Components : 
Epion E.C tablet formulated with dry extracts of most effective components including 65 mg from St. John's Wort (Hypericum perforatum L), 60 mg from Passion Flower (Passiflora incarnate L), and 30 mg from Valerian (Valeriana officinalis).

 
 

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